Incidence Rate: Scenario 2

Assumptions: Since we don't know the exact dates of exit, we assume that in each year when a subject exited he/she contributed only half a year to person-year experience of the cohort. Calculation of person-years: Contributed to follow-up in year 1: - 2 3 5 8 Contributed to follow-up in year 2: - 2 3 5 8 Contributed to follow-up in year 3: - 2 3 5 8 Contributed to follow-up in year 4: - 2 4 6 8 Contributed to follow-up in year 5: - 2.5 4.5 6.5 8 Contributed to follow-up in year 6: - 2 3 5 8 Contributed to follow-up in year 7: - 2 3 5 8 Total PYO accumulated through 7 years of follow-up: - 14 22.5 27 28

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