Data Analysis
The data collected yield the following counts:
Total number of Cases:
112
Total number of Controls:
224
Number of Cases who ingested Endurobrick:
28
Number of Controls who ingested Endurobrick:
56
Number of Cases who consumed Quench-it:
50
Number of Controls who consumed Quench-it:
56
8. How would you set up the classic 2x2 table using the above information to test the hypothesis that cases are more likely to have ingested EnduroBrick than controls?
- See the 2x2 table
- Calculate the odds of exposure among cases
- Calculate the odds of exposure among controls
- Calculate the exposure Odds Ratio (OR)
- Calculate the odds of Susser Syndrome among the exposed
- Calculate the odds of Susser Syndrome among the unexposed
- Calculate the disease Odds Ratio
- Interpret your findings
none:
  | Case | Control | Total |
---|---|---|---|
Exposed (Endurobrick) | 28 | 56 | 84 |
Unexposed (No Endurobrick) | 84 | 168 | 252 |
Total | 112 | 224 | 336 |
none:
Odds of exposure among cases (# of Cases exposed) / (# of Cases unexposed)
28 / 84 = 0.333
none:
Odds of exposure among controls (# of Controls exposed) / (# of Controls unexposed)
56 / 168 = 0.333
none:
OR = (Odds of Exposure among Cases) / (Odds of Exposure among Controls)
(28/84) / (56/168) = 1.0 or 0.33 / 0.33 = 1.0
none:
Odds of disease among exposed (# of Cases Exposed) / (# of Controls Exposed)
28 / 56 = 0.50
none:
Odds of disease among unexposed (# of Cases Unexposed) / (# of Controls Unexposed)
84 / 168 = 0.50
none:
OR = Odds of disease among Exposed / Odds of disease among Unexposed
(28/56) / (84/168) = 1.0 or 0.50 / 0.50 = 1.0
none:
Individuals with Susser Syndrome (cases) have the same odds of having ingested EnduroBrick as those without Susser Syndrome (controls). Conversely, individuals who ate EnduroBrick have the same odds of developing Susser Syndrome as those who did not eat EnduroBrick. An Odds Ratio = 1.0 suggests that there is no association between Susser Syndrome and EnduroBrick ingestion.
9. How would you set up the classic 2x2 table using the above information to test the hypothesis that cases are more likely to have consumed Quench-It than controls?
- See the 2x2 table
- Calculate the odds of exposure among cases
- Calculate the odds of exposure among controls
- Calculate the exposure Odds Ratio (OR)
- Calculate the odds of Susser Syndrome among the exposed
- Calculate the odds of Susser Syndrome among the unexposed
- Calculate the disease Odds Ratio
- Interpret your findings
none:
Case | Control | Total | |
---|---|---|---|
Exposed (Quench-it) | 50 | 56 | 106 |
Unexposed (No Quench-it) | 62 | 168 | 230 |
Total | 112 | 224 | 336 |
none:
Odds of exposure among cases (# of Cases exposed) / (# of Cases unexposed)
50 / 62 = 0.806
none:
Odds of exposure among controls (# of Controls exposed) / (# of Controls unexposed)
56 / 168 = 0.333
none:
OR = (Odds of Exposure among Cases) / (Odds of Exposure among Controls)
OR = (50/62) / (56/168) = 2.4 or 0.806 / 0.333 = 2.4
none:
Odds of disease among exposed (# of Cases Exposed) / (# of Controls Exposed)
50 / 56 = 0.893
none:
Odds of disease among unexposed (# of Cases Unexposed) / (# of Controls Unexposed)
62 / 168 = 0.369
none:
OR = Odds of disease among Exposed / Odds of disease among Unexposed
OR = (50/56) / (62/168) = 2.4 or 0.893/0.369 = 2.4
none:
Individuals with Susser Syndrome (cases) have 2.4 times higher odds of having consumed Quench-It than those without Susser Syndrome (controls). Conversely, individuals who drank Quench-It have a 2.4 times higher odds of developing Susser Syndrome than those who did not drink Quench-It. The OR = 2.4 supports a positive association between Susser Syndrome and Quench-It consumption.
10. Now you must present your findings to your supervisor. What is your recommendation?
- Both the data on EnduroBrick and Quench-It consumption were inconclusive. The study should be repeated with more participants.
- While ingestion of EnduroBrick does not cause Susser Syndrome, the data do indicate that consumption of Quench-It does cause Susser Syndrome.
- The data suggest that the consumption of Quench-It is associated with later development of Susser Syndrome whereas the ingestion of EnduroBrick does not appear to be associated with Susser Syndrome. You suggest that you should explore other potential exposure sources to rule out other potential causes of Susser's Syndrome as well as to further characterize this association.
After reporting your results, you decide to do a little bit more detective work. You head over to the Public Health Laboratory records department and check the log file on Quench-It. Since its production, the Health and Food Safety Inspector has taken random samplings of Quench-It back to the lab to analyze for any possible contamination. This is a routine surveillance procedure. Looking over the file you notice something interesting . Since 2002, a substantial amount of SUPERCLEAN has been found in Quench-It, probably a result of the bottle sterilization process. Following the Department of Health's repeated and stern demands, Glop Industries has recently changed its production techniques, and now Quench-It is now completely free of SUPERCLEAN. Those who consumed Quench-It prior to these changes, however, might have been exposed to trace amounts of SUPERCLEAN