Quiz 8, Module Randomized
8. What is the purpose of Intent-to-Treat analysis?
- To ensure a valid comparison between those who actually took the drug and those who did not.
- To maintain the comparability between the treatment and exposure groups that was obtained through randomization.
- To ensure comparability between the treatment groups at baseline.
Answer (a) —
incorrect:
Intent-to-Treat compares individuals based on treatment assignment, regardless of whether or not they actually took the drug.
Answer (b) —
correct:
Not using Intent-to-Treat analysis means that the investigator is no longer assigning the exposure, and the "experimental" nature of the design is thus compromised. As a result, comparison groups may no longer be comparable with regard to different characteristics.
Answer (c) —
incorrect:
This is the purpose of randomization.
